The phrase "a significant hit with" is correct and usable in written English.
It can be used to describe something that has been very popular or well-received by a particular audience or group.
Example: "The new movie was a significant hit with both critics and audiences alike, earning rave reviews and high box office numbers."
Alternatives: "a major success with" or "extremely popular among".
His talent was such that the average listener noticed it right away, and he had a significant hit with his first single, "Moonlight in Vermont" (1952).
Sony Pictures, which scored a significant hit with Heaven Is for Real in 2014, is backing Miracles, which, like Heaven Is for Real, is based on a successful book.
If you conserve, you can get through a day's worth of usage, but the handset took a significant hit with Bluetooth (Android Wear!) and GPS enabled.
The remaining 75 sequences (38%) did not have a significant hit with other oomycetes or non-Hpa sequences in GenBank, suggesting that these genes are Hpa-specific.
Therefore, those CDSs that contained a significant hit with "SLT" domain were considered as containing a GH23 domain.
Out of the 1536 SNPs, 1412 and 1527 showed a significant hit with Arabidopsis genes or B. rapa sequences, respectively.
Had Jordan come back, the Clippers would have been considered strong contenders in the Western Conference; with his departure their prospects take a significant hit even with All-Stars Paul and Blake Griffin still under contract.
If the search resulted in a significant hit, annotated with a function in the electron transport chain, a second BLAST was performed against the mitochondrial genome of the protozoon Reclinomonas americana which has the largest number of mitochondrial-encoded proteins [ 47].
Further analysis of this globular domain using profiles for conserved domains showed that it gave a significant hit (e-value=.005 001) e-value=.005 001in profile.
Because of the evolutionary divergence between chicken and the majority of the sequences that populate GenBank, a Blast score >50 was considered a significant hit, and clones with scores<50 were excluded.
Reads with a significant hit to the qnr PSSM and that aligned with at least 25 amino acids with 90% sequence similarity to a known qnr gene were annotated as known.
