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However, there is a significant higher order clustering of pericentromeric heterochromatin (PCH) regions leading to the formation of distinct PCH clusters (chromocenters) well below the diploid chromosome/centromere number (2 n = 40) of mitotic and meiotic mouse cells (Brero et al. 2005; Hsu et al. 1971; Scherthan et al. 1996).
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In the presence of a significant higher-order interaction, the lower-order interactions and corresponding main effects are hard to interpret by themselves.
Thus, the group correlations have a significant higher-order contribution.
Similarly, there also was a significant higher-order interaction between covariate, pathotype and host variety in the ancova (Table 4).
Terms were excluded from the model by backward elimination (α = 0.05) if they did not explain a significant proportion of the variation in codon bias, and they were not involved in any significant higher order interactions.
Statistics revealed significant higher order interactions among factors and the combination of PDO containing 50% nHA incubated in 1× revised SBF resulted in maximum mineralization.
However, extensive experimental and numerical analyses by the present authors suggested that the narrowband noise attenuation due to sound path asymmetry involves significant higher order mode contributions, hence cannot be described in terms of the plane wave model.
In the literature, reaction norm models with significant higher order terms are exceptions [ 24, 25].
Only significant effects are reported (p < .05), whereas lower order effects in the omnibus analyses are only reported in case no significant higher order effects were found.
Thus, the significant centre by medication effect can be ignored because it was confounded with the significant higher order effect of gender by status by MED2 due to the hierarchical character of the model.
Thus, the minimal amount of H3K4me2 and its lack of specificity at the neocentromere suggest that it is unlikely to play a significant higher-order structural role in kinetochore formation at neocentromeres.
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