Sentence examples for a significant handicap from inspiring English sources

Every show that plays at 10 p.m. also carries a significant handicap now.

The lack of permanent leadership is a significant handicap, according to current and former regulators.

Compared with hip-hop heroes like these, Jay-Z has a significant handicap: he's alive and well.

In 2008, according to the conventional wisdom touted by campaign books, Bill's indiscipline was a significant handicap to her.

Today, consumers use them to buy nearly everything, from groceries to gasoline to psychic hotline calls, and not having one can be a significant handicap.

Resentment toward Karzai's corrupt administration has shaded over into anger at the international coalition that empowered him, and this anger has proven to be a significant handicap on international state-building efforts.

In this study, steroid use was associated with a 41% rate of significant handicap (severe neurologic deficit or Bayley PDI and/or MDI less than 70) among 63 dexamethasone treated infants, compared to a 31% rate among the 70 controls [ 17].

Additional research in a wider sample of individuals with significant handicap is needed to further support these findings and to fully understand the role of the better (leading) ear in limiting the degree of self-perceived hearing handicap.

This was a significant marketing handicap as titles are frequently used by theatre-goers in searching and buying tickets online.

Without treatment, the natural course of the disease will result in a significant visual handicap.

Major congenital malformations were those responsible for death, causing a significant future handicap or requiring major surgery, while minor congenital malformations comprised the remainder (8).