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The phrase "a significant group of" is correct and usable in written English.
It can be used to refer to a notable or considerable number of individuals within a particular category or context.
Example: "A significant group of researchers gathered to discuss the latest findings in climate science."
Alternatives: "a considerable number of" or "a substantial portion of".
Exact(60)
A significant group of backbenchers will vote against the rise.
He did represent a significant group of intellectual opponents to the EEC who were championed by the Spectator magazine.
A significant group of them are flat-taxers who are whispering about deep cuts to corporation taxes.
"There's a bit more introspection, at least from a significant group of people who have already made it.
"This is particularly dangerous in South Korea, where there is a significant group of people who think Seoul should be more independent of Washington and acquire nuclear weapons.
However, he added, "there is also a significant group of people who regard it as wrong, contrary to scripture and the fundamental teachings of the church".
Still, a significant group of senior administration officials, nominally led by Deputy Defense Secretary Paul D. Wolfowitz, continue to push the investigation into Iraq's possible involvement.
Comprising 434 genera and about 3,700 species, the carrot family (Apiaceae) is a significant group of flowering plants.
Staffordshire Police said a "significant group of home fans" were involved in concerted efforts to target police fan segregation lines.
These kinds of opportunities have helped a significant group of American artists carve out a middle-class living for themselves.
In Strasbourg a significant group of radicals, including Kaspar Schwenckfeld, Melchior Hofmann, and Sebastian Franck, gathered about 1529.
More suggestions(17)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com