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Supported by international funds (notably the Global Fund to Fight AIDS, Tuberculosis and Malaria), widespread deployment of ACTs in tropical countries has contributed to a significant global reduction in malaria.
Importantly, selective inhibition of JAK2 activity for 4 hours demonstrated a significant global reduction of H3Y41ph at the TSS of genes marked with this histone modification.
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One can envisage how loss of KDM2B would more dramatically affect this additional pool of H2AK119ub1 resulting in significant global reduction in its abundance.
For a large electrical transformer, the number of actuators and error sensors needed to achieve a significant global noise reduction can be up to hundreds, and this makes the convergence of the FXLMS algorithm very slow.
To the contrary, modelling results suggest that it could be possible to achieve significant global reductions in premature (under-70 years) NCD deaths if relevant risk factors were appropriately managed (40); however, the extent to which those risk factors are likely to be effectively managed in the countries reported here remains an important question.
Short-term in vitro arsenite treatment in lymphoblastoid cells clearly demonstrated a significant global hypomethylation, determined as reduction in LINE-1 methylation and total 5-MedC content, and p53 hypermethylation (p < 0.05).
Following short-term in vitro arsenite treatment, the dose-response and time-course study clearly demonstrated a significant global hypomethylation, observed as a reduction in LINE-1 methylation and total 5-MedC content in lymphoblasts exposed to arsenite (10-100 μM) for four hours, but not at two hours or eight hours.
Sepsis is a significant global health problem.
IUU fishing is a significant global problem.
Riverine flooding is a significant global issue.
Malaria remains a significant global health problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com