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The phrase "a significant gap in" is correct and usable in written English.
It can be used to describe a notable deficiency or lack in a particular area, such as knowledge, resources, or performance.
Example: "The study revealed a significant gap in the understanding of climate change among the general public."
Alternatives: "a considerable deficiency in" or "a notable shortfall in".
Exact(60)
There's a significant gap in that theory, however.
There is a significant gap in his offending.
The deal fills a significant gap in Facebook's service.
The upshot is a significant gap in our legal vocabulary.
This is a significant gap in his record.
Yet a significant gap in our understanding remains.
It is now widely accepted that there is a significant gap in the delivery of justice.
"This fills a significant gap in our collection of late Gothic, northern European sculpture".
Their move uptown also leaves a significant gap in the art world.
Congress defined a standard benefit, which includes a significant gap in coverage, also known as a doughnut hole.
The second is to identify a significant gap in someone else's proof and supply the missing chunk.
More suggestions(17)
a significant loophole in
a significant variance in
a prominent gap in
a significant shortcoming in
a sizable gap in
a vital gap in
a substantial gap in
a sizeable gap in
a noteworthy gap in
a major gap in
a huge gap in
a considerable gap in
a vast gap in
a salient gap in
a large gap in
a noticeable gap in
a remarkable gap in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com