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The phrase "a significant first step" is correct and usable in written English.
You can use it when discussing an important initial action or decision that leads to further progress in a project or initiative.
Example: "Implementing the new policy is a significant first step towards improving workplace safety."
Alternatives: "an important initial move" or "a crucial starting point."
Exact(60)
This is a significant first step toward securing his extradition.
"We think that this submission represents a significant first step," the company said.
We would rather have a significant first step toward coverage than no progress at all".
She said that the document submitted Thursday was "a significant first step toward developing detailed protocols".
"This is a significant first step," said Prof Anthony James at the University of California, Irvine.
Given Jordan's stature, there was speculation whether his endorsement of Bradley was a significant first step.
A technique representing a significant first step down that road has now been successfully demonstrated.
"It's a significant first step for the majority leader, who was entirely against pay-to-play reform," Mr. Pozycki said.
Ms. Wright, who reviewed a draft copy of the transfer plan at the request of The Times, said it was a significant first step that must go further.
The compromise on cancer drugs, they say, would be a significant first step toward solving the larger problem: millions of older Americans cannot afford the drugs they need.
A significant first step is what Oliver has done though his television programme – however, to continue the momentum, a multi-prong, community based effort is needed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com