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The phrase "a significant factor and" is correct and usable in written English.
It can be used when discussing elements that contribute to a particular outcome or situation, often in a list or comparative context.
Example: "In the success of the project, a significant factor and the team's dedication played crucial roles."
Alternatives: "an important element and" or "a key contributor and".
Exact(29)
Rarity is a significant factor, and ongoing archaeological digs can sometimes drastically increase the known numbers of a particular coin.
Rhythm is a significant factor, and movements are often clearly linked by a recognizable pattern of accents.
Cost remains a significant factor, and production costs need to be reduced by a factor of ten.
Moreover, at the turbidities we employed in the 10-gallon tank, multiple scattering was a significant factor, and as we point out in our paper, confocal imaging performs poorly in the presence of multiple scattering.
Writers on both sides see the Israeli elections as a significant factor, and wonder how Egypt will react.
The direct cost of PGx testing is not a significant factor and nullified the positive effect of clopidogrel stratification only if the cost exceeded $5,100.
Similar(31)
Environmental design concept is a significant factor, regionally and locally.
But even controlling for these factors, the researchers found that advanced maternal age was still a significant factor in and of itself.
Democrats are looking to address growing income inequality (of which wage stagnation is a significant factor) both regionally and up and down the economic ladder.
HF is one of the leading causes of hospitalisation, and is a significant factor for morbidity and mortality worldwide.
"This is unsustainable and will continue to be a significant factor in administrations and rising vacancies, unless addressed".
More suggestions(3)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com