The phrase "a significant extent when" is not correct as it lacks clarity and context in written English.
It can be used when discussing the degree to which something is true or applicable, but it needs to be part of a more complete thought.
Example: "The project was successful to a significant extent when the team collaborated effectively."
Alternatives: "a considerable degree when" or "a substantial amount when".
The periplasmic localization of Caa, under the conditions tested, was only observed to affect growth of the cells to a significant extent when cultivated in minimal media.
Therefore, the computational cost in the present solvation model can be saved to a significant extent when compared to the other methods that require the quantum chemical calculations or statistical modeling.
Disulfide formation appears to be the more favourable process, with sulfenic acid generation only occurring to a significant extent when the former cannot occur (e.g. due to steric constraints on proteins or absence of suitable thiols).
As seen in Figure 4A and B, Pro residues strongly reduce membrane insertion when located in the middle section of the H-segment and to a lesser but significant extent when near the ends.
We showed that species, but not traits, were strongly influenced by site effects, while traits were influenced by both 'terril' and successional effects to a significant extent, making traits more robust than species when trying to discern patterns of community response to soil and vegetation changes.
What happens when we come to see the world, to a significant extent, through the eyes of a handful of big companies based in California?
Finally, it is shown that lumped models may provide misleading predictions when simulating combustor monoliths where gas phase reactions occur to a significant extent.
When it comes to the experience of racial minorities, appearance is, to a significant extent, experience; a Klan member or a racist police officer won't ask a black person for a passport any more than for a diploma or a bank book before launching an epithet or an attack.
When the Federal Reserve is the ultimate economic regulator of the U.S. and to a significant extent the world, is it too much for it to have $10-20,000 10-20,000 dollars/liabilities per American of its bassets/liabilities
When executives make big strategic bets, they typically depend on the judgment of their teams to a significant extent.
