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The phrase "a significant extent in" is correct and usable in written English.
It can be used when discussing the degree or level to which something occurs or is true within a specific context.
Example: "The research indicates that climate change affects biodiversity to a significant extent in various ecosystems."
Alternatives: "a considerable degree in" or "a substantial amount in".
Exact(39)
"They act as a repeater to a significant extent, in that they refer audiences to sort of Russian stuff," he said.
Therefore, only the nonionized, lipid-soluble forms of organic chemicals are found to a significant extent in milk.
A literature survey shows that both centres vary to a significant extent in both clinical and computational experiments.
The effect of overdischarge was limited and Jahn Teller effect was overcome to a significant extent in this nano-crystalline film.
In contrast to hydrazine oxidation on platinum in acidic media, the stabilization of chemisorbed hydrazine does not occur to a significant extent in alkaline media.
There have been several studies in other fields addressing how experts develop their skills but not to a significant extent in systems engineering.
Similar(21)
This indicates that the (labelled) pyruvate pool is diluted by unlabelled lactate or in other words that extracellular lactate is metabolized to a significant extent even in the presence of glucose.
Synergy is expressed in the alloys down to remarkably low levels of Mo (<5 at%), and to a significant extent also in physical mixtures.
This problem can be overcome to a significant extent by in situ condensation of methanol during its synthesis which is possible nowadays due to the availability of highly active catalysts allowing for lower reactor temperatures.
Since carbohydrates reduce Cr VI) to a significant extent only in strongly acidic media, it is likely that the first Cr(V) complexes formed in biological systems upon the addition of Cr VI) are those of strong reductants, such as GSH or ascorbate [5].
To a significant extent, research in these categories will depend upon both the nature of the storm and the special characteristics of each location, including the vulnerability of the population at risk, the physical characteristics of the location, and the existing structural and institutional management measures that are in place.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com