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The phrase "a significant exposure" is correct and usable in written English.
It can be used in contexts discussing risks, health, or situations where someone is subjected to a notable level of something, such as a substance or influence.
Example: "The study revealed that workers had a significant exposure to hazardous chemicals in the manufacturing process."
Alternatives: "a considerable exposure" or "a substantial exposure".
Exact(37)
The Justice Department lawsuit "is a significant exposure," said Clifford A. Hewitt, an analyst with Legg Mason Wood Walker in Baltimore.
Describes two such situations: a significant exposure to the Canadian dollar with adverse accounting consequences and GM's exposure to the Argentinean currency when devaluation is widely anticipated.
In short, peer-dependent privacy has become a significant exposure for companies that want to ensure the highest standards of data protection, privacy, and regulatory compliance.
"They've had to be notified that they've had a significant exposure to prions because they are expected to take precautions.
"Although we have no evidence that anybody has received a significant exposure to make them sick at this 12-to-24-hour 12-to-24-hour 12-to-24-hour 12-to-24-hourd.
Credit unions with a significant exposure to assets or liabilities with embedded options should consider alternative measurement methods such as discounting along a yield curve (e.g. the U.S. Treasury curve, LIBOR curve) or using multiple interest rate paths.
Similar(23)
"This suggests that previous claims of a significant exposure-response relationship between diacetyl inhalation and respiratory disease in food/flavoring workers were confounded.
In the winter, only HR showed a significant exposure-related effect (p = 0.0194) using the 8-hr integrated data.
A significant exposure-response relationship was found between symptomatic knee OA and kneeling in men but not in women.
Hodgkin's disease was significantly increased in the 0.5 0.9 ppm group with a significant exposure-dependent trend.
Linear mixed models indicated a significant exposure-response association between PM2.5 exposure and urinary 8-OHdG levels (p = 0.03).
More suggestions(16)
a vital exposure
a huge exposure
a prominent exposure
a sizable exposure
a major exposure
a large exposure
a remarkable exposure
a significant issue
a significant breakthrough
a significant contribution
a significant lead
a significant shift
a significant offer
a significant gamble
a significant loss
a significant victory
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com