The phrase "a significant effort and" is correct and usable in written English.
It can be used when discussing the amount of work or resources required to achieve a particular goal or outcome.
Example: "The project will require a significant effort and collaboration from all team members to succeed."
Alternatives: "a considerable amount of effort" or "a substantial effort".
The United States has made a significant effort and investment in STEM education, yet the size and the composition of the STEM workforce continues to fail to meet demand.
That point -- peace is more than the absence of war, it's the presence of justice -- it meant that everybody's movement, that every effort to challenge injustice was a significant effort, and that if you brought people together challenging injustice, that that could allow you to develop the kind of broad-based power that could bend the political will toward justice and toward your objective.
Creating buyer profiles that your writers and teams can refer back to is a significant effort, and the output isn't content that can be shared with customers.
Joined by their colleague at Duke University, Professor Steve Cummer, Smith and Pendry began a more systematic analysis of the prospective cloak, and discovered the original Pendry design would require a significant effort and many months — if not years — of work.
Our analysis showed that formalising the meaning of bio-models requires a significant effort and is not trivial, since the meaning appears from several perspectives and in different facets (cf. Figure 1).
Increasing the pressure of ethylene, a practice that requires a significant effort and poses a safety hazard in batch mode, appeared to increase the reaction rate, furthermore, an excess of ethylene is essential to prevent homodimerization, thus the ability to work at increased pressures is an important consideration.
Hence, there continues to be a significant effort to identify and develop both peptidic and small, drug-like molecule inhibitors [1] of this particular serotype LC.
Few gay people I know are more than one degree away from a gay-bashing, and in almost every case, police fail to make a significant effort to find, and prosecutors to imprison, the criminals.
A significant effort has been and continues to be applied to the search for improved HCC biomarkers.
There is a significant effort in Canada and the United States towards the uptake of electronic medical records (EMRs) in an effort to obtain the benefits of a computerized health care system [ 5].
This was Mr. Ahmadinejad's only print interview on his visit to the United Nations General Assembly, and he made a significant effort to be friendly and conciliatory.
