The phrase "a significant drawback to" is correct and usable in written English.
It can be used when discussing a notable disadvantage or negative aspect of something.
Example: "One significant drawback to this new software is its high cost, which may deter potential users."
Alternatives: "a major disadvantage of" or "a considerable downside to".
A significant drawback to these analyses is that they do not take into account how far an object can be clearly seen and recognized.
For both species a significant drawback to the basin population is observed, with 1/3 for elm and ¼ for poplar after 25 years already.
A replacement of the inner reflector plug presents a significant drawback to the facility due to the activation and the operation cost.
As an example of the potential impact of such analysis, it is shown that for cores with CR below ∼0.8, the increase of neutron doses and decay heat can represent a significant drawback to implement the corresponding reactors and associated fuel cycles.
However, there is a significant drawback to all of these studies.
However, a significant drawback to PEI-mediated gene transfer delivery is that there still is no persistent transgene expression as there is no stable chromosomal integration [ 9].
And besides the steep price, there's really only one significant drawback to the Audio Bones — but it's a doozy: the sound quality isn't great.
One significant drawback to Sony's new devices is that, unlike the Kindle, they cannot connect wirelessly to an e-book store.
On the other hand the use of acoustic sensors has a significant drawback compared to RF systems.
Presently, this is a significant drawback with regard to supporting the collaborative and integrated design of mechatronic systems.
However, a significant drawback was the need to conduct multiple RED measurements which limited throughput and consumed expensive resources.
