The phrase "a significant drawback of" is correct and usable in written English.
It can be used when discussing a notable disadvantage or negative aspect of something.
Example: "One significant drawback of this new software is its high cost, which may deter potential users."
Alternatives: "a major disadvantage of" or "a notable downside of".
While dermal substitutes can mitigate scarring and wound contraction, a significant drawback of current dermal replacement technologies is the apparent delay in vascular ingrowth compared with conventional skin grafts.
The cost, time, and variability involved in ex vivo expansion or manipulation of cells to prepare them for transplantation is a significant drawback of such an approach.
A significant drawback of silicon anodes is the large volume change associated with the insertion and extraction of lithium, which oftentimes leads to cracking and pulverization of the anode, limiting its cycle life.
However, a significant drawback of acrylated materials is that free radical polymerization is strongly inhibited by oxygen scavenging of the free radicals.
A significant drawback of the triangulation method is the necessity that receivers be equipped with directional antennas, so that the angle at which an incoming transmission originates may be measured.
A significant drawback of preemptive solutions based on link quality monitoring is that they need successful packet reception in order to monitor the signal strength of the packets sent by a particular neighbor.
However, there is a significant drawback to all of these studies.
However, in these biocatalytic processes, biocatalysts must be cultivated, separated, and washed before being used in the production of acetoin; such a complicated operation presents a significant drawback for the application of the method.
There is a significant drawback for savers: the lack of any guarantee that you will get your money back.
"The fact that there wasn't some fat cat taking the profits, just some guy investing 50 or a hundred quid to get a little return and doing something good for someone else". There is a significant drawback for savers: the lack of any guarantee that you will get your money back.
However, a significant drawback for the widespread application of ZFN technology is the limited binding selectivity conferred by the zinc-finger modules, as well as complex context-dependent interactions between adjacent zinc fingers that can alter binding affinity to the DNA (Cornu et al., 2008; Händel et al., 2009).
