Sentence examples for a significant drawback however from inspiring English sources

A significant drawback, however, is the large dead time of the order of 1 ms per event generated by the use of a gating grid, which is mandatory to prevent ions created in the amplification region from drifting back into the drift volume, where they would severely distort the drift path of subsequent tracks.

A significant drawback, however, of explicit schemes is that they are susceptible to instabilities for larger iteration steps.

One significant drawback, however, is the large amount of memory needed to index the reads.

Nuclear imaging techniques have significant drawbacks, however, including radiotracer development at a cyclotron or reactor, radioactivity handling, and lack of any shelf life, causing difficulties with patient scheduling.

However, a significant drawback to PEI-mediated gene transfer delivery is that there still is no persistent transgene expression as there is no stable chromosomal integration [ 9].

However, a significant drawback of acrylated materials is that free radical polymerization is strongly inhibited by oxygen scavenging of the free radicals.

For gated and dynamic studies, the sinogram format is however a significant drawback as the sinogram size multiplies with the number of phases or time frames.

However, a significant drawback is that aluminum fluoride (AlFx) film will be easily formed on the etched sidewalls and wafer surfaces as soon as the Al2O3 material is exposed to fluorine-based plasmas.

However, a significant drawback of many of these strains is poor immunogenicity in immunocompetent animals, which appears to be a function of reduced growth and decreased antigen load.

However, a significant drawback was the need to conduct multiple RED measurements which limited throughput and consumed expensive resources.

However, a significant drawback in the use of aminoglycosides is their narrow therapeutic index, the potential for ototoxicity and nephrotoxicity and the need for monitoring of drug concentrations.