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The phrase "a significant discrepancy of" is correct and usable in written English.
It can be used when discussing a notable difference or inconsistency between two or more items, data sets, or situations.
Example: "The audit revealed a significant discrepancy of funds between the reported and actual amounts."
Alternatives: "a considerable difference in" or "a notable variation of".
Exact(6)
They neglect can lead to a significant discrepancy of up to 40percentt between pre- and post-calculation and thus to a loss of the corporate added value.
Although the inclination of FOP was closely related to the inclination of BOP, we found a significant discrepancy of the inclination of FOP and BOP within each group.
A significant discrepancy of 0.72 mmol between CO2 and H2 content occurred when C. hydrogenoformans was grown on pyruvate in both phases I and III, clearly indicating that part of the H2 produced was also consumed.
For all hybrid patterns of FRC, a significant discrepancy of mode II fracture toughness K IIc values (13 43 %) is clearly observed with small values of a/w, i.e. a/w = 0.3.
Dental midline differential (MLD), defined as the absolute difference between the incisal embrasure of the maxillary central incisors (Mx1) and the incisal embrasure of the mandibular incisors (Md1) from the sagittal plane, showed a significant discrepancy of 0.15 ± 0.20 mm (p < 0.0001).
From the study, we were able to confirm that a significant discrepancy of perception regarding primary care exists between physicians and patients.
Similar(54)
A significant discrepancy on anti-HCV activity of 5-HT2AR andantihistaminestisisthatnes is that PBZ inhibits both HCVcc and HCVpp, but CCZ exhibits no inhibitory effect on HCVpp (He et al., 2015).
The respondents strongly agree that there is a significant discrepancy in terms of visibility of the passenger approaches throughout the system.
Literatures report a significant discrepancy regarding definition of domestic violence among different cultures (Sokoloff & Dupont 2005; Fernandez 2006).
Our preliminary analysis indeed indicated that there was a significant discrepancy in amount of reported intergenerational support between parents who co-resided with a child and parents who did not (results available upon request).
There is no published evaluation of this in Australia; however, a significant discrepancy between the insertion of ventilation tubes and clinical guidelines was reported among New York metropolitan hospitals in the USA.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com