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Significant disc leakage is also noted.
The retina showed complete resolution of exudative detachment with pigmentary changes over the posterior pole, attenuated vessels, and significant disc pallor with few residual hemorrhages.
While IOP ≤ 22 mmHg with visual field loss and/or significant disc cupping cases were defined as having NPG.
However we have demonstrated that for each grade increase in disc degeneration (grades 2 to 4) there was significant disc narrowing at each lumbosacral level (all p ≤0.03).
Both rSOST treated and PGISp control mice had large numbers of severely affected intervertebral joints, with significant disc destruction and large-scale production of excess tissue (Fig. 4c).
We hypothesize that in the cytokine rich milieu of the degenerating disc cathepsin K plays a significant role in disc matrix degeneration.
The multivariate analysis adjusted for age, sex, disc degeneration and BMI still showed a significant correlation between disc herniation and NGF levels (P = 0.018).
In all PBS, PPP, and PRP groups, radiographs 4 weeks after the initial anular puncture showed a significant narrowing of disc height compared with that of the non-punctured L3/4 disc (approximately 24.0% decrease compared with the baseline percentage DHI values before anular puncture, P <0.01).
Calcification of the nucleus pulposus and/or the annulus fibrosus is a significant sign of disc degeneration in dachshunds and the distribution of detectable calcification in affected discs represents the distribution of a continuous variable.
Based on these data, we suggest that cathepsin K may play a significant role in disc matrix remodeling and in matrix degradation in the proinflammatory cytokine-rich microenvironment of the degenerating disc.
Based on these data, we propose that cathepsin K plays a significant role in disc matrix remodeling and in matrix degradation in the proinflammatory cytokine-rich microenvironment of the degenerating disc.
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