The phrase "a significant disadvantage of" is correct and usable in written English.
You can use it when discussing a notable drawback or negative aspect of a particular subject or situation.
Example: "One significant disadvantage of remote work is the potential for feelings of isolation among employees."
Alternatives: "a major drawback of" or "a considerable downside to".
However, the ground force has a significant disadvantage of not being a directly measurable parameter.
A significant disadvantage of the JP-5/H2O2 combination is that no high-performance engine utilizing it is currently available.
I wrestled with how to handle this issue in my Effexor talks, since I believed it was a significant disadvantage of the drug.
A significant disadvantage of the unit-cell modelling approach is that it does not account for the natural variations in microstructure that are typical for most foam structures.
A significant disadvantage of the integrated layout is the increased loss of unreacted methanol from its exhaust, which reduces efficiency and has safety implications.
A significant disadvantage of particle filter is computational complexity.
We suspect that if they establish that normal working time is 7 till 10 and Saturdays, if that's imposed for nurses, therapists, technicians, who are earning significantly less than doctors and are predominately female, the knock-on effect for the NHS will again be a significant disadvantaging of low-paid, female workers".
69 A significant disadvantage to the clinical use of raltegravir is the requirement for twice-daily dosing to achieve maximal efficacy.
Objective. Many teen parents and their babies are at a significant disadvantage because of poverty and inadequate parenting skills.
Several reports have found that rural businesses, schools and homes are at a significant disadvantage because of poor broadband.
Although these methods perform impressively well, they have a significant disadvantage, the lack of transparency, limiting the interpretability of the solution and thus the scope of application in practice.
