The phrase "a significant difficulty when" is correct and usable in written English.
It can be used to introduce a situation or context where a notable challenge arises.
Example: "There is a significant difficulty when trying to balance work and personal life."
Alternatives: "a major challenge when" or "a considerable obstacle when".
Patients who are "above average" in terms of speech understanding, can achieve 100% correct scores on the most difficult tests of speech understanding in quiet but also have significant difficulty when signals are presented in noise.
However, those means would meet significant difficulties when trying to effectively a grow material inside nanostructures, e.g., nanotubes [4].
Reports indicate that the most popular rigid body software for engineering simulation, which uses an approach based on the so-called "discrete element method," runs into significant difficulties when handling problems involving thousands of contact events.
Statistical inference allows investigators to reason about the general properties of populations from evidence based on samples, but has significant difficulties when applied to geographic data.
It should be blindingly obvious to all but the most naive that it will face significant difficulties when it needs to call on the very same bodies to help it.
While this may represent an advantage in some cases, as it allows for an in-depth investigation of the influence of the mixing field on the enhancement at various sites (see previous section), it raises significant difficulties when pyridine is used in imaging experiments.
First, the issue of distinguishing temporal from spatial variability is a significant difficulty for multi-pollutant sampling designs; when only a small number of homes can be sampled simultaneously, there is not adequate variability observed within any time period to distinguish the temporal from spatial effects.
A significant difficulty is the lack of familiarity of the housing sector with the concept of cohousing," she says.
A significant difficulty is that one cannot be sure that the sonnets are autobiographical.
This shows that a "significant difficulty still exists in both sampling and force field accuracy" [23].
