Sentence examples for a significant difficulty to from inspiring English sources

The phrase "a significant difficulty to" is correct and usable in written English.
It can be used when discussing a challenge or obstacle that poses a considerable problem or issue for someone or something.
Example: "The new regulations present a significant difficulty to small businesses trying to comply with the law."
Alternatives: "a major challenge for" or "a considerable obstacle to".

Exact(1)

The ~400 and 120 kDa bands were similarly active towards albumin and goat IgG at all the pH values tested, except for the case of goat IgG where these two bands displayed higher activity at pH 9. Of note, bands of 400 and 120 kDa displayed a significant difficulty to be separated in gels copolymerized with these two substrates.

Similar(59)

The proposed bill would place a larger burden of proof on the employer by raising the standard to a "significant difficulty" for the employer.

Symptoms may vary from alteration in the quality of voice to a significant difficulty in breathing depending upon the size and location of the disease in each case.

Reading disability (RD, also known as developmental dyslexia) refers to a significant difficulty in reading that cannot be explained by obvious causes, such as sensory impairments or lack of educational opportunity (Shaywitz et al. 1990).

Daniell et al. (2010) reported that economic losses not adjusted to current USD values are a significant difficulty when compiling earthquake data from different epochs.

A significant difficulty in comparing reports for different chemotherapy regimens in NETs relates to heterogeneity of this patient population.

A full day's drive to the clinic also means taking a day off of work, which is a significant difficulty for a low-wage worker in the Valley, which has one of the largest agricultural workforces in the United States.

A significant difficulty is the lack of familiarity of the housing sector with the concept of cohousing," she says.

A significant difficulty is that one cannot be sure that the sonnets are autobiographical.

This shows that a "significant difficulty still exists in both sampling and force field accuracy" [23].

While these analogies are certainly noteworthy, there is a significant difficulty with the central claim.

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