The phrase "a significant difficulty is" is correct and usable in written English.
It can be used when introducing a problem or challenge that is noteworthy or important in a given context.
Example: "A significant difficulty is the lack of resources available for the project, which hampers our progress."
Alternatives: "a major challenge is" or "a considerable obstacle is".
The most significant difficulty is the inability of these in vitro 3D models to fully mimic the defined in vivo 3D orientation, of either normal (i.e. polarity; distinct structural architecture) or aberrant (loss of structural integrity) epithelial cells, that dictates intracellular, intercellular and cell extracellular matrix (ECM) signaling [ 33].
Being wireless without significant difficulty was a revelation.
Using the higher (1.38 cubic metres per capita) estimate significant difficulties are evident for a number of, particularly Polynesian, countries.
Thompson said the number of people experiencing significant difficulties was low, around 1% of all applicants, and said the system was on course to meet the Department for Education's estimates for free childcare take-up by the end of August.
No significant difficulties were encountered when translating it from English to Italian, except for one question where the fact that the level of competition in the original text is described in relation to the American league system required adaptation to Italian professional sport categories.
The ~400 and 120 kDa bands were similarly active towards albumin and goat IgG at all the pH values tested, except for the case of goat IgG where these two bands displayed higher activity at pH 9. Of note, bands of 400 and 120 kDa displayed a significant difficulty to be separated in gels copolymerized with these two substrates.
The source observed that De Mistura appeared closer to the Russian position, quoting him as saying there was a "significant difficulty" in implementing what was requested from Russia, and that it would be "easier" for the three other countries to implement the requests of Russia and Iran.
While these analogies are certainly noteworthy, there is a significant difficulty with the central claim.
