The phrase "a significant difficulty in" is correct and usable in written English.
It can be used when discussing challenges or obstacles encountered in a specific context or situation.
Example: "There is a significant difficulty in implementing the new software system across all departments."
Alternatives: "a major challenge in" or "a considerable obstacle in".
We address a significant difficulty in the numerical computation of fluid interfaces with soluble surfactant that occurs in the physically representative limit of large bulk Peclet number Pe.
This meshless method is ideally suited to the simulation of cold spray as very large material deformations can be readily accommodated, whereas this is often a significant difficulty in mesh based techniques.
The source observed that De Mistura appeared closer to the Russian position, quoting him as saying there was a "significant difficulty" in implementing what was requested from Russia, and that it would be "easier" for the three other countries to implement the requests of Russia and Iran.
A significant difficulty in comparing reports for different chemotherapy regimens in NETs relates to heterogeneity of this patient population.
Such annotations, which are clearly a consequence of high-throughput experiments, present a significant difficulty in method evaluation.
Symptoms may vary from alteration in the quality of voice to a significant difficulty in breathing depending upon the size and location of the disease in each case.
A significant difficulty, detailed in Theoretical results, is that marginalization over variables outside the { M1, M2, E1, E2} subnetwork might add statistical dependencies not suggested by Model 1 or Model 2 and make our likelihood ratio test inconsistent.
This shows that a "significant difficulty still exists in both sampling and force field accuracy" [23].
The ~400 and 120 kDa bands were similarly active towards albumin and goat IgG at all the pH values tested, except for the case of goat IgG where these two bands displayed higher activity at pH 9. Of note, bands of 400 and 120 kDa displayed a significant difficulty to be separated in gels copolymerized with these two substrates.
A full day's drive to the clinic also means taking a day off of work, which is a significant difficulty for a low-wage worker in the Valley, which has one of the largest agricultural workforces in the United States.
In total, 38.5% of prostate patients reported some degree of urinary leakage, 12.9% reported difficulty controlling their bowels and 58.4% reported being unable to have an erection with a further 11% reporting significant difficulty in having or maintaining an erection.
