The phrase "a significant difficulty for" is correct and usable in written English.
It can be used when discussing challenges or obstacles that affect a person, group, or situation.
Example: "The lack of funding presents a significant difficulty for the project's success."
Alternatives: "a major challenge for" or "a considerable obstacle for".
The complexity of hardware design methodologies represents a significant difficulty for non-hardware focused scientists working on accelerating the simulation of complex bio-inspired applications.
The lack of knowledge about particle behavior in combined sewer detention tanks remains a significant difficulty for the design of these works.
A full day's drive to the clinic also means taking a day off of work, which is a significant difficulty for a low-wage worker in the Valley, which has one of the largest agricultural workforces in the United States.
Theoretical calculation reveals that V is a dopant element for the n-type diamond semiconductor, but strong structural distortion is a significant difficulty for doping V into the diamond lattice.
The proposed bill would place a larger burden of proof on the employer by raising the standard to a "significant difficulty" for the employer.
The adoption of K coefficients posed a significant difficulty for local authorities.
A significant difficulty in comparing reports for different chemotherapy regimens in NETs relates to heterogeneity of this patient population.
Additionally, the analyses revealed a significant main effect for difficulty (F1,125 = 77.32; p <.001) and a significant difficulty by importance interaction (F1,125 = 8.05; p <.01).
The charter provided for the college to operate at both Canonsburg and Washington, a position that caused significant difficulty for the administration trying to rescue the college amid ill feelings over the unification.
