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The phrase "a significant difference when" is correct and usable in written English.
It can be used to indicate a notable distinction that occurs under specific circumstances or conditions.
Example: "There is a significant difference when comparing the results of the two experiments."
Alternatives: "a notable difference when" or "a considerable difference when".
Exact(60)
Interestingly, peak intensities of 1533.4, 2211.5, and 4418.9 Da also showed a significant difference when the two different degree GDM groups were compared.
We compared the RNA concentration in the different samples and found a significant difference, when comparing the primary group, the recurrent group and the non-recurrent group.
The applicability of the In-RATE to published randomized trials in four frequent tumour types (colorectal, non-small cell lung, advanced ovarian and metastatic breast cancers) was suggested to more precisely distinguish the effects of different drugs, and sometimes to detect a significant difference when the published data did not conclude to statistical difference.
Yet the president drew the contrast on Thursday in California when, appearing with Gov. Arnold Schwarzenegger, a Republican, he said, "It makes a significant difference when you have somebody in the Statehouse willing to take the lead".
Single asterisk connotes a significant difference when compared with the vehicle-treated group (P < 0.05).
Generally, the fiber modifications did not have the desired effect of improving the mechanical properties further, while for the thermal properties, there was a significant difference when chemically modified fibers were used.
Firstly, there was a significant difference between the obese group and the other two groups (p = 0.023) and secondly there was a significant difference when the obese group was compared to the normal weight group (p = 0.008).
Oscar noticed a significant difference when he morphed into Oscar.
The researchers found a significant difference when the exercise was performed aloud in the presence of someone else, even though the participants had heard nothing.
That is, any possible bias was not strong enough to show a significant difference when the markers were swapped.
At P23 following continued treatment with epoetin delta, there was still a significant difference when compared to control (Figure 9B).
More suggestions(12)
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a major difference when
a substantial difference when
a considerable difference when
a significant difference after
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com