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The phrase "a significant difference was observed between" is correct and usable in written English.
It can be used in scientific or analytical contexts when discussing the results of a study or comparison between two or more groups or variables.
Example: "In the experiment, a significant difference was observed between the control group and the experimental group in terms of their response rates."
Alternatives: "a notable difference was noted between" or "a marked difference was detected between".
Exact(60)
A significant difference was observed between Christians and Muslims with respect to the use of spirituality/prayer as a CAM modality.
Episode percentages tended to be greater when the degree of mutation was greater, and a significant difference was observed between the CC and TT alleles (P < 0.01).
A significant difference was observed between the drainage versus no-drainage groups regarding postoperative complications and hospital stay (P =.001, both groups).
A significant difference was observed between properties of complexes formed in solution and those formed at the interface, especially for R = 100.
In thermogravimetric analysis data above 300 °C, however, a significant difference was observed between the three sorts of hybrids with Cal, Ara, and ACC, respectively.
No significant differences could be observed concerning the test drivers' gaze between old or modern objects, but a significant difference was observed between the test drivers' gaze between road stretches with faraway objects and stretches without objects.
A significant difference was observed between the classic IAP and the MIAPri in our clinical study.
A significant difference was observed between 0 and ≥ 8 weeks (Fig. 5).
Again, a significant difference was observed between the treatments (p = 0.05).
A significant difference was observed between actual body weight (ABW), measured on ICU admittance, and either IBW or PBW.
A significant difference was observed between the low/medium IT groups and the high IT group (P < 0.05).
More suggestions(15)
a significant decrease was observed between
a significant difference was determined between
a significant interaction was observed between
a slight difference was observed between
a strong difference was observed between
a significant difference was detected between
a significant difference was found between
a significant association was observed between
a marked difference was observed between
a clear difference was observed between
a significant correlation was observed between
a small difference was observed between
a statistical difference was observed between
a corresponding difference was observed between
a significant difference was noted between
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com