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The phrase "a significant difference is" is correct and usable in written English.
It can be used when discussing or comparing two or more items, indicating that there is an important distinction between them.
Example: "In the study, a significant difference is observed between the control group and the experimental group in terms of their performance."
Alternatives: "a notable difference exists" or "there is a meaningful difference".
Exact(60)
When pinching the MP and PIP joints, the gliding ratios of rest-50rest-50%andrest-80rest-80%h statistical significance (P < 0.05), while a significant difference is observed in the rest-50% pinching force when pinching the DP.
Presently, a significant difference is observed in probabilities of failure amongst the four different arrangements of ply lay ups in composite design.
A significant difference is observed in kinetic parameters of rice husk for different varieties which indicates that design parameters for industrial processes of rice husk would be different.
In between the two frescoes a significant difference is also evident that can be imputed to a different distance and angulation of the spotlights; the following higher illuminance is measured by the Hobo 10 located on the altar that, as said above, is the only zone lit by daylight (Figure 2).
A significant difference is found between the failure probabilities based on the two criteria.
A significant difference is well recognized between the structural seismic design and progressive collapse design.
"But the idea that this can be replicated to a large enough extent to make a significant difference is completely fatuous.
But a significant difference is intimacy: most of the subjects are friends or former students and he has personal anecdotes to go with each painting.
The results are also statistically compared, and a significant difference is observed between the SPSO and the LFPSO methods.
As it turns out a significant difference is obtained for both calculations showing the importance of anisotropic models for these loading situations.
However, a significant difference is the orientation of the catalytic domain relative to the coenzyme-binding domain that results in a larger interdomain cleft.
More suggestions(16)
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a remarkable difference is
a large difference is
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a salient difference is
a substantial difference is
a noticeable difference is
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com