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Three reasons have been presumed for this poor correlation: (a) significant difference in the half lives of proteins, (b) inability to get a clear picture because of significant amount of error and noise in both protein and mRNA experiments, and (c) various complicated posttranslational modifications [ 23].
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We explored potential differences in personal cumulative risks based on race in NYC, because approximately half the teenagers were African American and half were from Hispanic origin (data not shown), but did not find a significant difference in the distributions.
There was no significant difference in the half-life of cyclin D1 during G1 and S phases in the NIH 3T3 cells.
We analyzed previously published transcriptome-scale experimental data on RNA half-lives in fibroblasts and B-cells [ 26] and found a significant difference in half-life time distribution between eRNAs and intracellular RNAs.
PK analyses of FVIII products have not revealed a significant difference in half-life and clearance between VWF-containing or high-purity FVIII products.
But only half of the comparisons with a significant difference in branch length show more genetic change in the domesticated lineage, a pattern indistinguishable from chance.
Nearly half of the CpGs in human liver show a significant difference in methylation comparing fetal and adult samples.
Nearly half of the CpGs in human liver show a significant difference in methylation comparing mid-gestation fetal and adult samples.
Although we find a statistically significant difference in the number of cigarettes smoked per day, there is no documented evidence that a difference of one half of a cigarette a day will make a significant difference in health outcomes.
Especially in half-marathons, there was no age difference but a significant difference in performance between Africans and Non-Africans.
Ripken has made a significant difference in major league baseball.
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