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The phrase "a significant difference characterizes" is correct and usable in written English.
It can be used when discussing how a notable distinction defines or distinguishes a particular subject or phenomenon.
Example: "In this study, a significant difference characterizes the outcomes of the two treatment groups, highlighting the effectiveness of the new medication."
Alternatives: "a notable difference defines" or "a marked difference distinguishes".
Exact(1)
We previously studied the large SOA-BR LHON family from Brazil and an Italian cohort of 39 LHON families demonstrating that a significant difference characterizes unaffected mutation carriers compared with affected individuals in terms of mtDNA copy number and mitochondrial biogenesis, both of which are activated more efficiently in unaffected mutation carriers.
Similar(58)
The KHOMC V p profile can be characterized by a significant difference in the radial V p gradient between the shallower 300 km and the deeper part of the upper 700 km of the core.
Pelota from Thermoplasma acidophilum and Dom34 from S. cerevisiae have been structurally characterized, revealing a tripartite architecture with a significant difference in their overall conformations.
In this work, we characterize the dendritic transcriptome of mouse and rat hippocampal neurons to assess whether a significant difference exists in these two closely related species.
Reversing that would make a significant difference.
"But is it a significant difference?
There is a significant difference, however.
Fees can make a significant difference.
Could Mathieu Flamini make a significant difference?
Will they make a significant difference?
From a student activist perspective, there was a significant difference".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com