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The phrase "a significant difference between these two" is correct and usable in written English.
It can be used when discussing or comparing two items, concepts, or groups to highlight a notable distinction.
Example: "There is a significant difference between these two approaches to problem-solving, which can affect the outcome of the project."
Alternatives: "a notable difference between these two" or "a marked difference between these two".
Exact(26)
Statistical analysis revealed a significant difference between these two independent proportions (one-tailed p < 0.023, see Table 6).
When compared to the respective intact values (1.67 ± 0.24 mm), there was still a significant difference between these two states (p = 0.0001).
The morphing conditions were considered as within-subjects factor (designs), statistical analysis (ANOVA) shows a significant difference between these two groups of normalized response times (F=15.22,p<.001).
The limits of agreement between TTE- and PAC-derived MPAP were similar for mechanically ventilated and spontaneously ventilating patients, but the study was underpowered to detect a significant difference between these two groups.
A significant difference between these two halves of the New Productivity Decade is that during the second half, globalization and IT dramatically expanded the capacity of workers from around the world to contest American middle-class service jobs.
A significant difference between these two conditions is predicted.
Similar(34)
There is a significant difference between the two, and addressing that difference should have a profound impact on development.
There should be a significant difference between the two responses, even in young babies," she adds.
Kornblatt finds a significant difference between the two generations, however.
No parameter showed a significant difference between the two periods.
No statistically significant difference between these three AUROCs, p = 0.9.
More suggestions(16)
a meaningful difference between these two
a phenomenal difference between these two
a significant interaction between these two
a minor difference between these two
a major difference between these two
a great difference between these two
a final difference between these two
a significant relationship between these two
a big difference between these two
a subtle difference between these two
a functional difference between these two
a key difference between these two
a structural difference between these two
a significant correlation between these two
a marked difference between these two
a genuine difference between these two
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com