The phrase "a significant deletion of" is correct and usable in written English.
It can be used when discussing the removal or omission of a substantial amount of content or information from a text or document.
Example: "The editor noted a significant deletion of several paragraphs that altered the overall meaning of the article."
Alternatives: "a considerable removal of" or "a major omission of".
The collection of MITE instances were postprocessed to identify nested MITEs and possible parent autonomous elements because criteria used in the original Vmatch search would not identify TIRs separated by extraordinary distances, which could arise due to displacement of TIRs by nested elements or an autonomous state prior to any significant deletion of the inter-TIR region.
We did not find significant deletion of these cells from the peripheral circulation when ART was stopped and unfettered HIV replication returned.
Interestingly, only those Smad7liver-KO mice with significant deletion of Smad7 had severely decreased body weight (Figure 2C, left panel), accompanied by robustly elevated blood levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (Figure 2B and 2C).
In this study we describe, for the first time, significant deletion of genes involved in the Wnt signaling pathway, implying genetic inactivation of this important signaling pathway, in human osteosarcoma.
Analysis of previously published OS aCGH data (GSE9654) and aCGH data from this study (GSE19180) identified significant deletion of WWOX in 30% (6/20) of OS samples, whilst significant increase in both RUNX2 and VEGFA gene copy numbers were detected in 55% (11/20) and 60% (12/20) of OS samples, respectively.
Thus, our data demonstrate multiple pathways for L1 integration in cultured cells, and show that L1 is not simply an insertional mutagen, but that its retrotransposition can result in significant deletions of genomic sequence.
In comparison to their mammalian counterparts, viral serpins contain significant deletions of elements of secondary structure.
Gilbert et al reported that LINE-1 retrotransposition could result in significant deletions of genomic sequence [ 34].
No genes responsible for MYCN amplification have yet been identified and there is no consensus on the definition of prognostically significant deletions of 1p so that no single uniform method to detect 1p deletions could be used.
Hence, we provided the first evidence of significant deletions of Wnt signaling pathway genes in human osteosarcoma, findings which demonstrate that this important signaling pathway is genetically inactivated in osteosarcoma.
