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The phrase "a significant deficiency of" is correct and usable in written English.
It can be used when discussing a notable lack or shortfall of something, often in a formal or academic context.
Example: "The report highlighted a significant deficiency of resources in the department, which hindered project completion."
Alternatives: "a considerable lack of" or "a major shortfall of".
Exact(14)
This is due to a significant deficiency of moisture in the superficial layers of the ground and is related to the types of animal colonies.
A significant deficiency of the production, which otherwise is effectively staged by John Wooten, the company's producing artistic director, is the unconvincing sound design.
The report called the lack of such knowledge a "significant deficiency". Of the 20 missing laptops for which information was available, ATF indicated that seven -- 35percentt -- held sensitive information.
A significant deficiency of traditional road data models, being non-integrated 1-D, 2-D and 3-D roadatata, was eliminated by means of the newly developed methodology, Dynamic Reference Transformation, for transformations.
Using a different set of wild-type arrangements, Levine [16] observed a significant deficiency of wild-type non-recombinants relative to mutant non-recombinants in three of four crosses (Figure S1).
Figure 2B shows a SNP with a significant deficiency of heterozygotes.
Similar(46)
In addition, the Ire1α mutant D443A also exhibited a significant deficiency in downregulation of the RIDD mRNA substrates Blos1 and Scara3 (Hollien et al., 2009).
Cholinergic dysfunction has been implicated in the clinical symptoms of dementia, 38– 40 and postmortem studies have identified a significant deficiency in the activity of choline acetyltransferase in the brains of individuals with dementia.
A single human chromosome (HSA4) contained a marginally significant deficiency of Ambystoma orthologies (p = 0.50), however, given the large number of comparisons, a similar deviation would be expected to occur by chance.
In cell lines from 20 patients with schizophrenia and 20 normal controls, cells from patients show a significant deficiency in the range of NRG1α-induced adhesion (p = 0.0002).
Tests of departure from HW equilibrium (Table 1) show no significant deviation for porpoises from Iberia and the Black Sea, but a significant deficiency in heterozygosity at 9 of the 10 loci analysed in the NAt cluster.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com