Sentence examples for a significant defect of from inspiring English sources

Nevertheless, presumed silent mutations including synonymous and intronic mutations also showed a significant defect of homozygotes in L er collection, whereas this was not observed for missense mutations.

The early diagnostic procedure was used to make an early assessment of cardiac anatomy and in case of a significant defect to perform early intervention and to prevent pulmonary arterial hypertension in defects with a left to right shunt.

This is consistent with previous results that demonstrated a significant defect in differentiation of Wwox KO calvarial osteoblasts ex vivo compared to WT osteoblasts [16].

Similarly, SodB was underrepresented in the Δppk2 OMC; the sodB mutant of 81-176 has been shown to have a significant defect in the invasion of INT407 cells.

ICOSL−/− mice also had a significant defect in the number of central memory phenotype CD4 T cells, but this was neither as consistent nor as dramatic as the defect observed in the EM phenotype CD4 T cell population.

ICOS−/− mice had similar numbers of naïve and central memory phenotype CD4 T cells compared to wild-type mice but had a significant defect in the number of EM phenotype CD4 T cells (Figure 1B).

Herein, we describe a significant defect in the number of effector memory (EM) phenotype cells in ICOS−/− and ICOSL−/− mice that becomes progressively more dramatic as the mice age.

This despite a significant defect in the expression of acute-phase-response genes in IL-6−/−/LDLR−/− Paigen diet fed mice.

This suggests a significant defect in the machinery of meiotic chromosomal segregation or recombination, presumably leading to some reduction in fitness.

By 48 h, there was a significant defect in the ability of Δp66 bacteria to cross the cell monolayer compared with WT and p66 cc bacteria (Fig. 5).

Our results show that the p.S466L mutation does not cause a significant defect in tetramer formation of the protein, although there may be a slight reduction in the amount of higher-order octamer observed.