Sentence examples for a significant defect in from inspiring English sources

These cells showed a significant defect in DNA ligation, which was rescued by addition of recombinant FUS or by correcting the genomic FUS mutations.

Importantly, a marked decrease in the capacity of AMA1 to co-immunopurify RON2 was observed in the RON2IL/AA compared with RON2WT (Fig. 3c) that correlated with a significant defect in invasion (Fig. 3d).

C Feeding suppression induced by 1% 1-octanol shows a significant defect in ser-2 or tyra-2 mutants.

ATG5-/ progenitors exhibited a significant defect in B cell development at the pro- to pre-B cell transition, although a proportion of pre-B cells survived to populate the periphery.

However, deletion of the slpA gene caused substantial alterations in cell envelope structure, and a significant defect in resistance to solvent and shear stresses compared to the wild-type.

The research group of Dr. G. D'Amico generated PTX3-deficient MSCs (PTX3−/−-MSCs) [18], which showed a significant defect in promoting tissue repair in a mice model of wound healing compared to wild-type MSCs (WT-MSCs) [18].

In their study, certain site-directed mutants of vRdRP, "T173A" or "F176A" substitution in PA subunit of vRdRP, were shown to have a significant defect only in cRNA template binding, but not vRNA template binding.

Nevertheless, presumed silent mutations including synonymous and intronic mutations also showed a significant defect of homozygotes in L er collection, whereas this was not observed for missense mutations.

Darwin's twist on this response to the argument from design is to point out that it would be a particularly significant defect in the divine design of human beings if part of their very purpose in life were to suffer.

A statistically significant defect in O2 consumption rate was observed in intact SH-SY5Y cells expressing L347P and E417G PINK1 using pyruvate as a respiratory substrate, compared to the wild type PINK1 controls (Figure 5A).

Reductions in red cell counts, hematocrit and hemoglobin concentrations suggested a more significant defect in hematopoiesis and beyond the scid mutation (Qing et al., 2012).