A significant decrease in the level of testosterone was observed in the intoxicated animals, while the levels of FSH, LH and prolactin were significantly increased.
Moreover, association between the lack of testosterone and stimulating inflammatory responses has been shown and thus a remarkable improvement of cardiac performance and a significant decrease in the level of serum TNF-alpha following testosterone therapy has been suggested [ 33].
In this study, there was also a significant decrease in the bone resorption marker urinary deoxypyridinoline with testosterone treatment (Amory et al 2004).
Treatment of rats with GSTT during overtraining dramatically increased the serum level of testosterone and led to a significant decrease in the serum level of corticosterone.
Body weight, testis weights, epididymis weight and the serum testosterone and androstenedione levels showed a significant decrease in the three treated groups.
Furthermore, although the level of plasma testosterone is normal 7 days after SPS exposure, we found a significant decrease in the expression of androgen receptor protein in this spinal center.
Similarly, there was a significant decrease in free testosterone but not in total testosterone.
As expected, castration caused a significant decrease in serum testosterone levels.
By observing the integrity of the epididymal sperm plasma membrane, mitochondrial function, and DNA integrity, we found that naturally aged rats appeared to have abnormal sperm quality and a significant decrease in serum testosterone levels.
In the current study and our previous work [ 2], a significant decrease in testosterone in all CaCl2-treated groups was measured, despite the fact that serum testosterone remained within normal physiological levels over a 12 month period.
