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The phrase "a significant decrease in the prevalence" is correct and usable in written English.
It can be used in contexts discussing changes in the frequency or occurrence of a particular condition or phenomenon, often in research or health-related discussions.
Example: "The study revealed a significant decrease in the prevalence of smoking among teenagers over the past decade."
Alternatives: "a notable reduction in the occurrence" or "a marked decline in the frequency".
Exact(18)
Lastly, we observed a significant decrease in the prevalence of myeloid-derived suppressor cells and regulatory T-cells in the tumor microenvironment on day 7 post challenge with 4TO7-B7-1/GPI-IL-12 cells, which provides mechanistic insight into antitumor efficacy of the tumor-cell membrane expressed IL-12.
Models using the levels of Zn that can now be achieved in polished rice suggest that the increase in Zn will lead to a significant decrease in the prevalence of Zn deficiency in both adults and children in rural Bangladesh ([Arsenault et al. 2010]).
Use of ITNs was also associated with a significant decrease in the prevalence of light microscopy positive P. falciparum but not with LDR-FMA positive P. falciparum or P. malariae infections.
After 2003, a significant decrease in the prevalence of SSRIs in children, particularly paroxetine and citralopram, was found.
For boys, there was a significant decrease in the prevalence of meeting the PA guideline only during childhood but not during adolescence.
We observed a significant decrease in the prevalence of HIV among new injectors from 34% and 39% in 2005 and 2007 to 16% in 2009.
Similar(41)
Three years after the introduction of these measures, we noted a significant decrease in the incidence and prevalence of AES-I infection [ 14].
A significant decrease in the DSL further contribute to the decrease of the E2E.
A statistically significant decrease in the prevalence of syringe sharing was observed in the non-incarcerated group (p < 0.001); the decrease in the incarcerated group was not statistically significant (p = 0.398).
Somewhat surprisingly, recent prevalence estimates of maternal anaemia in pregnancy in the UK and other high-income countries, suggest there has been no significant decrease in the prevalence of anaemia in pregnancy in the last decade [ 1].
Despite these efforts, no significant decrease in the prevalence of scabies and body louse infestation was observed during the study (5 ).
More suggestions(16)
a significant reduction in the prevalence
a significant decrease in the infection
a significant decrease in the frequency
a significant decrease in the morbidity
a large decrease in the prevalence
a significant decrease in the incidence
a major decrease in the prevalence
a significant decrease in the proportion
a significant decrease in the frequencies
a clear decrease in the prevalence
a significant decrease in the maximum
a significant variation in the prevalence
a progressive decrease in the prevalence
a slight decrease in the prevalence
a marked decrease in the prevalence
a steady decrease in the prevalence
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com