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The phrase "a significant decrease in the mean" is correct and usable in written English.
It can be used in contexts such as statistical analysis, research findings, or discussions about data trends where you want to highlight a notable reduction in an average value.
Example: "The study revealed a significant decrease in the mean score of participants after the intervention."
Alternatives: "a notable reduction in the average" or "a marked decline in the mean value."
Exact(56)
Current results revealed a significant decrease in the mean of mice spleen and thymus relative weights by exposure to CMZ.
Results: There was a significant decrease in the mean MCSA of the submandibular gland and the CT number of both glands with age.
Furthermore, there was a significant decrease in the mean total PKC activity in the malnourished macrophages compared with results in controls (110,000 ± 8000 versus 60,000 ± 4000 cpm, P <.01).
A significant decrease in the mean value of salinity tolerance, expressed by survival time in 35-ppt seawater, was observed in both the full-sib mated line and the closed line of n=10, indicating inbreeding depression for salinity tolerance.
As Fig. 3 illustrates, there is a significant decrease in the mean debt level of 14.44 % for the treatment group from 2012 to 2013, while this reduction was only of 1.78 % for the control group.
This result was similar to that of Kehoe et al. [13], who found a significant decrease in the mean concentration of PGE2 levels in the PDL exudates of guinea pigs in whom ibuprofen had been administered.
The data showed a significant decrease in the mean numbers of monthly migraine days after therapy with CGRP-mAbs compared with placebo, from a baseline to weeks 1 4, 5 8, and 9 12.
Similar(4)
The mean 10-year CHD risk also showed a significant decrease in the intervention group (P = 0.001).
The long-term hope is a significant decrease in the city's reliance on fossil fuels.
There was a statistically significant decrease in the mean ISQ values between 1 and 3 weeks (P < 0.05).
Patients with metastatic melanoma had a significant decrease in MAMC mean (95% CI change)=−1(−0.2−0.2) cm (P<0.05).
More suggestions(9)
a significant decrease in the amount
a significant decrease in the expression
a significant decrease in the average
a significant difference in the mean
a significant decrease in the prevalence
a significant decrease in the incidence
a significant increase in the mean
a significant decrease in the rate
a significant decrease in the level
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com