The phrase "a significant decrease in the expression" is correct and usable in written English.
It can be used in contexts discussing changes in levels of expression, such as in scientific or medical research, particularly in relation to gene expression or protein levels.
Example: "The study revealed a significant decrease in the expression of the targeted gene after treatment with the new drug."
Alternatives: "a notable reduction in the expression" or "a marked decline in the expression."
We found a significant decrease in the expression of cathepsin K on day 1, when IFN-γ was expressed at its highest level.
On further evaluation of the molecular mechanisms underlying the senescent response, a significant decrease in the expression levels of HERC5 was noted.
This group showed a significant decrease in the expression of the convulsive activity and spectral potency in gamma and theta bands.
QRT PCR analysis of the anti-CEACAM1 treated ES cells revealed a significant decrease in the expression of Ceacam1, Pecam1, Tie-1, and Flk-1, while VE-Cad and Tie-2 expression were unaffected.
We observed a significant decrease in the expression levels of TNFR1, TRADD, TRAF2 and RIP in pM-treated 4910 and 5310 cells.
Interestingly, mutations in the Sp1 binding site of human resistin showed a significant decrease in the expression of luciferase reporter gene.
Furthermore, although the level of plasma testosterone is normal 7 days after SPS exposure, we found a significant decrease in the expression of androgen receptor protein in this spinal center.
Although the level of plasma T is normal 7 days after SPS exposure, we found a significant decrease in the expression of AR but not ERα protein in the upper lumbar spinal cord.
As we expected, western blot analysis revealed a significant decrease in the expression of DMT1−IRE protein as well as iron content in the neurons infected with siRNA DMT−IRE.
In a recent study on a larger number of mice (n = 10), however, a significant decrease in the expression of Cldn11 in SCARKO testes was confirmed over the entire period studied (day 4 50) [23].
The impaired development of BAT is underscored by a significant decrease in the expression of UCP1, which could be the consequence of altered BAT development, as illustrated by the decrease of PPARγ2 and its coactivator PGC-1α.
