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The phrase "a significant decrease in levels of" is correct and usable in written English.
It can be used when discussing changes in quantities or measurements, particularly in scientific, economic, or statistical contexts.
Example: "The study revealed a significant decrease in levels of pollution in the river over the past decade."
Alternatives: "a notable reduction in amounts of" or "a marked decline in quantities of".
Exact(17)
This would lead to a significant decrease in levels of social segregation, while also giving all schools a fairer chance of improving their performance.
The patients also showed a significant decrease in levels of pain within each training session.
We also found a significant decrease in levels of hypoxanthine and in the ratios of major metabolites of the purine pathway in plasma of PD patients.
Six out of 14 patients showed a significant decrease in levels of PSA.
Despite the overall differences in the metabolic response to P limitation, both genotypes experienced a significant decrease in levels of Pi.
Overexpression of HBD but not HA-HBDΔ protected stability of endogenous MAP1S and led to a significant decrease in levels of mHTT aggregates.
Similar(43)
There was a significant decrease in the levels of insulin hormone in ethanol administration (P < 0.05).
First, among those who currently own Prada and Banana Republic items, there was a significant decrease in the level of prestige of the Prada brand.
We found that mnb1 displayed a significant decrease in the level of phospho-Synj, while the total level of Synj as detected by Synj-1 remains unchanged (Fig. 4f, g).
In TRE4 only mice, we also observed a significant decrease in the level of apoE in brain homogenates.
Presently, BPA administration produces a significant decrease in serum level of testosterone when compared with control group.
More suggestions(17)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com