The phrase "a significant decrease in expression of" is correct and usable in written English.
It can be used in scientific or academic contexts, particularly when discussing changes in gene or protein expression levels.
Example: "The study revealed a significant decrease in expression of the target gene after treatment with the drug."
Alternatives: "a notable reduction in expression of" or "a marked decline in expression of".
There was a significant decrease in expression of this rate-limiting carbon fixation enzyme in B. sphaerulata holobionts incubated at 34 °C/8 °C above ambient (~ 50% decline relative to controls), but expression was resilient to levels of warming up to 6 °C above ambient.
In conclusion, sufficient uptake of SN38-PEG-PLGA-Ver NPs and a significant decrease in expression of ABCG2 and an increase in expression of BAX and BAX/BCL2 ratio was observed after treatment with nanoparticles compared with free SN38.
Hence, the prolonged antagonism of mGluR5 leads to a significant decrease in expression of mGluR1 only, and this effect is specific to the dentate gyrus.
When bacteria were grown in MB and Brain Heart Infusion with NaHCO3 (BHIN) plus lactose, pH was reduced to 5.5 5.9 and there was a significant decrease in expression of the locus of enterocyte effacement (LEE) genes eae, tir, espD, grlA/R and ler, and an increase in cya (cAMP), and two negative regulators of the LEE, gadE and hfq.
There was also a significant decrease in expression of ChAT (p<0.01 and p <0.001 for 100 nM and 5 µM, respectively) and the neurotrophin receptor p75NTR (p<0.05 and p<0.01 for 100 nM and 5 µM, respectively) following Aβ1 40 treatment (Figure 2A).
A significant decrease in expression of genes that generate the negative limb of circadian rhythms occurred in PER1, CRY1, NR1D1, BHLHB2 and CSNK1E, respectively, by 40 %, 60 %, 60 %, 70nd 80% and 80%the transition from pregnancy to lactation in the mammary glanduring
Beyond passage seven, several of the inflammatory genes began to show a significant decrease in expression.
Animals injected with 17-AAG also showed significant decrease in expression of VEGFR-2 (Fig 5C).
A significant decrease in the expression of TIP60, H3K9ac, H3K14ac and H2AK5ac was found following the elevated expression of UHRF2 in HCC tissues (Fig. 6A).
This is further supported by a significant decrease in gene expression of the inflammatory mediators TNF-α (100% decrease) and IFN-γ (100% decrease).
Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR−/− compared to AhR+/+ cells.
