We observed a significant decrease in cell proliferation, invasion and migration in miRNA-1260b knockdown PC-3 and DU-145 cells compared with inhibitor-NC transfected cells.
Integrin β1 knockdown resulted in a significant decrease in cell proliferation and invasion.
Introduction of hsa-miR-520h resulted in a significant decrease in cell migration and invasion, but with no significant effects on cell proliferation, cell cycle distribution, or apoptosis.
In contrast, there was a significant decrease in cell migration and invasion towards 10% fetal bovine serum (FBS) in stable Crk knockdown cells compared to control cells.
Finally, Id1 knockdown in SGC cells also produced a significant reduction in cell invasion.
Similarly, we observed a significant decrease in invasion of HepG2 cells transfected with C2GnT1 shRNA compared to cells transfected with a control vector, (mean number of cells/field = 14 versus 99, p<0.0005) (Fig. 6B, E, and F).
A significant decrease in the invasion ability of cancer cells confronted with IL-10-stimulated macrophages was observed upon EGFR silencing, even when comparing with AGS cells transfected with Lipofectamine only.
We previously showed a significant decrease in matrix invasion after AFAP1L1 knocking-down in U2OS cells 11.
In contrast, miR-199a-5p inhibition led to a significant decrease in GC9811-P cell in migration and invasion.
