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In addition, the knockdown of PERK suppressed the expression of phospho-PERK, phospho-eIF2α, ATF4, and CHOP, resulting in a significant decrease in cell apoptosis after the treatment with GalN/TNF-α.
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Transfection of the four pancreatic cancer cell lines with either Icat or dn-Lef-1 led to a significant decrease in cell proliferation and a marked increase in apoptosis (Fig. 3C, E).
PKC δ knockdown cells displayed a protection towards oxLDL-induced apoptosis as demonstrated by a significant decrease in cell death.
Introduction of hsa-miR-520h resulted in a significant decrease in cell migration and invasion, but with no significant effects on cell proliferation, cell cycle distribution, or apoptosis.
However, we observed a significant decrease in WFA-induced apoptosis in cells expressing the mutated vimentin, and we noticed a dramatic decrease in both vimentin degradation and caspase-3 activation (Figure 4C).
First, in each experiment, DIAP1, an important regulator of apoptosis, and therefore of cell viability [22] was depleted leading to a significant decrease in the cell number [23] (not shown).
There was a significant decrease in the cell turnover index (CTI; proliferation/apoptosis).
Exposure of oral premalignant and cancer cells to curcumin resulted in significant decrease in cell viability and induced apoptosis.
KL knockdown showed a small, but significant, decrease in cell viability compared with the control siRNA, and was associated with an increase in apoptosis.
Abrogating the signaling activation by a dual tyrosine kinase inhibitor in combination with conventional therapy can induce a significant decrease in proliferation of tumor cells and significant apoptosis of both tumor cells and endothelial cells.
LPS (10 μg/mL) induced significant inhibition of cell proliferation and cell apoptosis, and a significant decrease in the BCL2/BAX ratio in the cells cultured with 5.5 mmol/L glucose.
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