Sentence examples for a significant constraint effect from inspiring English sources

It is worth noting that the selection effect (positive or negative) is expected to identify patterns of natural selection acting on mildly deleterious mutations (negative selection) and advantageous mutations (positive selection), whereas a significant constraint effect in addition to negative selection allow identifying genes under strong negative or purifying selection (Eilertson et al. 2012).

This bias represents a significant constraint on the effectiveness of risk communication.

Thus, partial correlation analysis reveals that fRNA coverage imposes a significant constraint on sequence evolution, especially on synonymous sites after correcting for the effect of codon usage bias.

Voluntary reporting has been a significant constraint on past attempts to count police use of force.

But overall they function as a significant constraint on this presidency.

Yet the Obama administration faces a significant constraint in declaring a threat to Iraqi Kurdistan a threat to US interests.

But there is little question that fear of aerial interdiction has been a significant constraint on Peruvian drug production.

a significant constraint.

The nature of the current Syrian environment is a significant constraint on any investigation.

61 percent said budgets were a significant constraint when meeting the cybersecurity challenge.

The equal treatment norm, strictly interpreted, is a significant constraint on policy choice.