The phrase "a significant concern when" is correct and usable in written English.
It can be used to introduce a situation or context where a particular issue or problem is important to consider.
Example: "There is a significant concern when evaluating the environmental impact of the new construction project."
Alternatives: "a major issue when" or "a critical factor when".
Low- to medium-quality evidence is also mounting for its use in bone and joint infections, including chronic osteomyelitis, although adverse effects are a significant concern when long-term use is necessary.
Therefore, we evaluated the possibility that population substructure exists among unrelated mice from different CRL breeding facilities, which would be a significant concern when using CD-1 mice for genome-wide association studies (GWAS).
For example, the potential for vaccine-induced inflammation in the lungs is a significant concern when considering the development of nasally-administered vaccines for use in humans since murine nasal immunization studies have demonstrated the induction of antigen-specific IgE and airway inflammation when potent adjuvants such as cholera toxin are used [22], [67].
Animal welfare is a significant concern when culling methods are involved in wildlife disease management.
The technique, however, is vulnerable to nondesirable side products such as primer dimers or mispriming to nontarget sites, a significant concern when a sample contains thousands of transcripts.
Despite B cell depletion, there was no increase in the incidence of infection, which had been a significant concern when the drug was originally investigated.
This is another significant concern when it comes to patient care.
This can be a significant concern, particularly when striving for absolute quantification of TCRs.
Despite better control of inflammation, some patients still report pain as a significant concern, even when being in clinical remission.
My family and community members who chose to keep their hair have had significant concerns when donning a dastaar, a Sikh turban, to work or school, concerned that they will be a target for physical or verbal violence, given the marginalization they've experienced when adopting a physical Sikh identity in their homeland, America.
This is of significant concerns when considering actual operating conditions, in particular, sudden and severe electrical load change.
