The phrase "a significant concern is" is correct and usable in written English.
It can be used when introducing a topic or issue that is important or troubling in a discussion or analysis.
Example: "In the context of climate change, a significant concern is the rising sea levels that threaten coastal communities."
Alternatives: "a major issue is" or "an important worry is".
With digital S.L.R. cameras, a significant concern is whether the sensor chip, which is exposed to the environment when the camera's lens is removed and the shutter is opened, has been soiled or damaged.
A significant concern is how populations will respond to such rapid and novel environmental changes (Sutherland et al. 2013).
With both approaches (combination therapy or BAX/BAK activators), a significant concern is that these will cause unacceptable toxicity in healthy tissue.
Despite the encouraging decrease in malaria incidence rates in Africa, a significant concern is the extent to which the increase in allergy will exacerbate the burden of malaria.
A significant concern is the high seroprevalence among US blood donors (18 21%) compared with individuals professionally exposed to swine HEV, such as veterinarians (23 26%).
A significant concern was that screening rates for syphilis had dropped since 1999 due to lack of RPR kits and staff were discouraged about the quality and effectiveness of the service that they were able to provide.
A very significant concern is ensuring protection against brain aging.
Despite the encouraging recent decrease in malaria incidence rates, even in rural areas, an additional significant concern is the extent to which such an increase in allergy will exacerbate the burden of malaria.
Bettridge: A much more significant concern is that previous use of cannabis, in any capacity, could result in individuals being denied entry into the United States.
One area of significant concern is custody.
A more significant concern was that some supplements labeled gluten-free were found to contain wheat and other potential allergens not listed on the label.
