The phrase "a significant clinical issue" is correct and usable in written English.
It can be used when discussing important problems or challenges in a clinical or medical context that require attention or intervention.
Example: "The rise in antibiotic resistance has become a significant clinical issue that healthcare providers must address."
Alternatives: "a major clinical concern" or "an important clinical problem".
The safety of electroconvulsive therapy (ECT) in patients who have deep brain stimulation (DBS) implants represents a significant clinical issue.
Imatinib intolerance is a significant clinical issue which leads to dose reduction or discontinuation.
Emergence agitation is a significant clinical issue during recovery from general anaesthesia.
As the number of different AAI designs has increased, Device Switches have become a significant clinical issue.
The lack of robust information available to guide clinical decisions in the subgroup of patients with T1aN0 or T1bN0 HER2+ tumours remains a significant clinical issue.
Since mealtime insulin dose is a major determinant of postprandial glycemic control, improving the insulin algorithm is a significant clinical issue.
In many cases these involved significant clinical issues such as incorrect name, strength or active ingredient of a medicine on the packaging or errors in the product information leaflet in relation to administration or toxicity.
Currently, ovarian carcinoma presents significant clinical issues, as the 5 year survival rate for all stages and types is 44%%, while stage IV invasive ovarian carcinoma has a 5 year survival rate of 17%% [ 41].
The selection of candidates for BRCA germline mutation testing is an important clinical issue yet it remains a significant challenge.
Residual and significant postinfarction left ventricular (LV) dysfunction, despite technically successful percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI), remains an important clinical issue.
Concordance is an important clinical issue in primary care.
