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In a significant climb down, the broadcasters – led by the BBC – have proposed a new format for their election coverage which would include just one seven-way television debate.
Apple's shares are up 30percentt on the year, but it'll still require a significant climb if the company is going to cross that semi-vanity mark.
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The compromise marked a significant climb-down for the government in Belgrade, which has made joining the E.U. its overriding goal, even as it has remained unequivocal that it considers Kosovo its medieval heartland and has fought an unsuccessful campaign to have Kosovo's unilateral declaration of independence deemed illegal.
Soon-to-be official GOP nominee Mitt Romney faces a significant uphill climb with Latino voters, according to a weekly tracking poll released Monday, showing just how much he still has to prove this week at the Republican National Convention.
Widely considered to be on the fringes of potential contention before this rash of injuries, they will now face a significant uphill climb to remain relevant into the season's second half.
Sanders has faced a significant uphill climb on his quest for the Democratic presidential nomination ever since Clinton's strong showing in the March 1 "Super Tuesday" primaries, but has managed to stay in the race with a string of victories in Western states and an upset in Michigan.
And if they can no longer be trusted to respect the riders by observing the etiquette of normal civilised behaviour, then the Tour's organisers should recognise their own responsibility by placing barriers along the final 5km of every significant climb, maybe also banning the ubiquitous and unsightly motor homes from the verges.
— After two days of sprint finishes by a largely intact peloton, the Tour of California will receive a sharp jolt Wednesday, when the route includes two significant climbs in what will probably be the toughest day of riding in the Tour's three-year history.
By contrast, overexpression of TBPH in motor neurons (D42 > TBPH) had no effect in larval stages, and adult flies exhibited significant climbing deficits relative to controls within a week of eclosion (supporting information, Figure S1).
Most of the significant climbs in the Tour route are given a 1 to 4 score, with 1 being the hardest, 4 the easiest.
Before 1850 the British had done no significant climbing in the Alps.
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