Sentence examples for a significant change however from inspiring English sources

The phrase "a significant change however" is correct and usable in written English.
It can be used to introduce a contrast or exception to a previous statement regarding a notable change.
Example: "The project was progressing smoothly; a significant change, however, was needed to meet the new requirements."
Alternatives: "a notable shift nonetheless" or "a considerable alteration, on the other hand".

Exact(1)

If there is not a significant change, however, the official said, "there would not be a need for another public comment period around that route".

Similar(59)

No significant change, however, was observed in the plasma concentration of AM.

No significant change, however, was observed in the level of IL-1β.

Gene expressions between the control and the CCCM stimulated groups showed no significant change; however, expression of these genes was partially restored by 3D ECT in vitro culture.

Perhaps the most significant change, however, has been the scaling up of the ART programs in public sector health systems and the gradual but significant closing of the "treatment gap".

There are a few areas where we're likely to see significant changes, however.

No significant changes however was observed in other treatment groups.

There were no significant changes, however, in incidence stratified by the number of comorbid diseases.

No statistically significant changes, however, were observed overall in urinary IsoP or γ-tocopherol.

The increases showed no statistically significant changes, however, between women and men and between all age groups.

Significant changes, however, must be appraised with respect to the changes in the single items and possible coexisting or newly occurring diseases [ 39].

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