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The phrase "a significant change for" is correct and usable in written English.
It can be used when discussing an important or impactful alteration that affects a person, group, or situation.
Example: "The new policy represents a significant change for the employees, as it alters their work schedules and benefits."
Alternatives: "a major shift for" or "an important transformation for".
Exact(60)
He said it would mark a significant change for the way corporations are governed.
The new position reflects a significant change for the Police Department.
The ending of "about" collection is a significant change for the N.S.A.'s post-Sept.
But the possibility of ending it entirely would prove a significant change for the nation.
The statements from Mr. Moussawi mark a significant change for Iraq.
A campaign that began last month signals a significant change for Maaco.
The shift was a significant change for the Boy Scouts, where membership has slipped in recent decades.
In a significant change for this tumultuous state, home to the Zapatista guerrilla group, no serious violence was reported.
Mr. Kalanick's leave will be a significant change for a company that was molded in his image.
The recent regulatory scrutiny represents a significant change for consultants, which have long enjoyed a privileged status in Washington.
Experts who attended closed government-sponsored meetings on the project said the fact that critics were allowed to voice concerns represented a significant change for China.
More suggestions(16)
a vast change for
a large change for
a noteworthy change for
a remarkable change for
a tremendous change for
a notable change for
a momentous change for
a significant alteration for
a considerable change for
a nice change for
a significant driver for
a significant milestone for
a big change for
a significant step for
a good change for
a significant opportunity for
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com