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The phrase "a significant challenge to" is correct and usable in written English.
It can be used when discussing obstacles or difficulties that pose a serious threat or problem to something or someone.
Example: "The new regulations present a significant challenge to small businesses trying to comply with the law."
Alternatives: "a major obstacle for" or "a considerable difficulty for".
Exact(60)
"We're a significant challenge to them…and insurance is a $180 billion a year market in the US".
"It's a significant challenge to overcome," Keleher said.
"This was a significant challenge to his leadership".
Management of fungal biofilms represents a significant challenge to healthcare.
Still, the square and its problems pose a significant challenge to the center's audience-building efforts.
This is a significant challenge to the traditional political methodology of social democracy.
"This is a significant challenge to which we expect the BBC to make a significant response".
In addition to the environmental impact, hops pose a significant challenge to brewers.
Although marginal, these independent operations were numerous enough to present a significant challenge to Bell.
Maternal mortality and morbidity still pose a significant challenge to policy makers and health professionals.
Feeding a growing global population in a changing climate presents a significant challenge to society.
More suggestions(16)
a substantial challenge to
a considerable challenge to
a notable challenge to
a momentous challenge to
a tremendous challenge to
a significant difficulty to
a vast challenge to
a sizeable challenge to
a significant problem to
a huge challenge to
a major challenge to
a large challenge to
a significant threat to
a significant challenging to
a significant setback to
a significant contributor to
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com