Sentence examples for a significant challenge of from inspiring English sources

But Carolina's defense will face a significant challenge of its own.

Since the area averages nearly 600 inches of snow every year, Mr. Grigg's architects were given a significant challenge of creating a structure that can withstand the weight of the snow.

The management of the open abdomen, particularly when complicated by the presence of intestinal fistula, remains a significant challenge of modern trauma care.

A significant challenge of providing healthcare to patients with low HL is the complex nature of the disease process, and of requisite treatments.

Identification and confirmation of functional variants remains a significant challenge of investigations involving genome-wide association studies (GWAS).

This has led to a significant challenge on the utilization of high carbon-containing resource such as coal.

They have also highlighted that the tremendous diversity of the microbiome presents a significant challenge for analysis of human microbiome data.

Therefore, an efficient thermal management of high-powered electronic equipment is a significant challenge for cooling of data centres.

The mobility of the migrant and seasonal farmworkers presents a significant challenge to investigations of long-term health effects (Quandt et al. 2002).

A significant challenge for these state-of-the-art analyses is that they must be done competently.

Indeed, the complex, disputed relationship between the two makes disability a significant challenge for theories of justice.